Fmoc-Val-Cit-PAB-PNP

Storage: 2-8 °C for short period. Long time storage -20 °C

Synonym: {4-[(2S)-5-(carbamoylamino)-2-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanamido]pentanamido]phenyl}methyl 4-nitrophenyl carbonate

Uses: Cathepsin cleavable linker. Fmoc is an amine protecting group. PAB is a self-immolative spacer that connects to amine or hydroxyl-containing payloads via a carbamate or carbonate bond respectively. The PNP carbonate is a highly activated leaving group that facilitates the attachment of the payload to the linker during ADC synthesis.