DBCO-PEG4-Val-Ala-PAB-PNP

Storage: - 20 °C

Synonym:

Uses: Cathepsin cleavable linker. PAB is a self-immolative spacer that connects to amine or hydroxyl-containing payloads via a carbamate or carbonate bond respectively. The PNP carbonate is a highly activated leaving group that facilitates the attachment of the payload to the linker during ADC synthesis. DBCO enable click chemistry with azide molecules. PEG spacer increases aqueous solubility.