6-Azidohexanoyl-Val-Cit-PAB-PNP

Storage: -20 °C

Synonym: 6-azido-N-((S)-1-hydroxy-1-(((S)-5-((hydroxy(imino)methyl)amino)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxopentan-2-yl)imino)-3-methylbutan-2-yl)hexanimidic acid

Uses: Cathepsin cleavable linker. PAB is a self-immolative spacer that connects to amine or hydroxyl-containing payloads via a carbamate or carbonate bond respectively. The PNP carbonate is a highly activated leaving group that facilitates the attachment of the payload to the linker during ADC synthesis. Azido group enable click chemistry with DBCO, BCN or other Alkyne group.