MC-Val-Ala-PAB-PNP

Storage: - 20 °C, protect from light, stored under nitrogen

Synonym: 4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)propanamido)benzyl (4-nitrophenyl) carbonate

Uses: Cathepsin cleavable linker. Maleimidocaproyl (MC) is used for bioconjugation to thiols in antibodies. PAB is a self-immolative spacer that connects to amine or hydroxyl-containing payloads via a carbamate or carbonate bond respectively. The PNP carbonate is a highly activated leaving group that facilitates the attachment of the payload to the linker during ADC synthesis.