DBCO-PEG4-Val-Cit-PAB-PNP

Storage: -20°C

Synonym: 4-((17S,20S)-1-(DBCO-Butanedicarboxylamino)-17-isopropyl-15,18-dioxo-20-(3-ureidopropyl)-3,6,9,12-tetraoxa-16,19-diazahenicosan-21-amido)benzyl (4-nitrophenyl) carbonate

Uses: Cathepsin cleavable linker. PAB is a self-immolative spacer that connects to amine or hydroxyl-containing payloads via a carbamate or carbonate bond respectively. The PNP carbonate is a highly activated leaving group that facilitates the attachment of the payload to the linker during ADC synthesis. DBCO enable click chemistry with azide molecules. PEG spacer increases aqueous solubility.