Mal-Dap(Boc)-Val-Cit-PAB-PNP

Storage: -20°C

Synonym: tert-butyl (S)-2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-((S)-3-methyl-1-((S)-1-(4-(((4-nitrophenoxy)carbonyloxy)methyl)phenylamino)-1-oxo-5-ureidopentan-2-ylamino)-1-oxobutan-2-ylamino)-3-oxopropylcarbamate

Uses: Cathepsin cleavable linker. Mal-Dap(Boc) is a stable maleimide based linker used for bioconjugation to thiols in antibodies. PAB is a self-immolative spacer that connects to amine or hydroxyl-containing payloads via a carbamate or carbonate bond respectively. The PNP carbonate is a highly activated leaving group that facilitates the attachment of the payload to the linker during ADC synthesis.