Mal-amide-PEG8-Val-Ala-PAB-PNP

Storage: - 20 °C

Synonym: 1-((3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-1-hydroxypropylidene)amino)-N-((S)-1-hydroxy-3-methyl-1-(((S)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxopropan-2-yl)imino)butan-2-yl)-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-imidic acid

Uses: Cathepsin cleavable linker. The maleimide is used for bioconjugation to thiols in antibodies. PAB is a self-immolative spacer that connects to amine or hydroxyl-containing payloads via a carbamate or carbonate bond respectively. The PNP carbonate is a highly activated leaving group that facilitates the attachment of the payload to the linker during ADC synthesis. PEG spacer increases aqueous solubility