Fmoc-Val-Ala-PAB-PNP

Storage: -20 °C

Synonym: (9H-fluoren-9-yl)methyl ((S)-3-methyl-1-(((S)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxopropan-2-yl)amino)-1-oxobutan-2-yl)carbamate

Uses: Cathepsin cleavable linker. Fmoc is an amine protecting group. PAB is a self-immolative spacer that connects to amine or hydroxyl-containing payloads via a carbamate or carbonate bond respectively. The PNP carbonate is a highly activated leaving group that facilitates the attachment of the payload to the linker during ADC synthesis.